The Toxicogenomics Project and drug safety evaluation

Toxicogenomics Investigation Under the eTOX Project

Exploiting the Japanese Toxicogenomics Project for Predictive Modelling of Drug Toxicity

Motivation In the last decade, surprisingly few drugs reached the market. Many promising drug candidates (approx. 80%) failed during or after Phase I, inter alia, due to issues with undetected toxicity [1]. The problem of undetected toxicity becomes even more apparent in the context of drug-induced illness which causes approximately 100,000 deaths per year solely in the USA [2]. Toxicogenomics ...

Drug Safety Evaluation

Despite the considerable number of newer antibacterials made available over the past decades, amoxicillin, alone or in combination with clavulanic acid, still accounts among the most widely used antibacterial agents. Although they are often considered ‘twin drugs’, they are different both in terms of antibacterial activities and of safety profile. It is well documented that the clavulanate comp...

Relationship between Safety Investment and Safety Performance Indices Considering the Project Hazard Level in Construction Industry

Introduction: Each country needs to preserve its human capital through preventing accidents for its development. Therefore, this study is carried out to study the relationship between safety investments and safety performance indices considering the interactive effect of the project hazard level in construction industry. Material and Methods: This study was conducted using multiple case studie...

Percellome toxicogenomics project and its possible contribution to 3R's

Percellome Toxicogenomics Project has been launched to develop the comprehensive gene cascade database/ informatics for the mechanism-based predictive toxicology. For an effective accumulation of transcription data, a normalization method designated as "Percellome" is developed. By this method, mRNA expression values are given as "copy numbers per one cell" from microarrays. Thus, data are read...